Saul Villa

Publications with green marking on the journal name are available as PDF files. To view the pdf files, you need to have installed "Acrobat Reader". Other papers are available as a reprint request by mail.

You have requested access to material protected by copyright. We considered your request as reprint request as is common in the scientific community. When you download a PDF, you agree to download one copy for personal and scientific use only. Commercial use or duplication is not allowed unless a permission from the copyright owner is granted.

Publications in scientific journals


  1. Carrasco-Torres, G., Fattel-Fazenda, S., Lopez-Alvarez, G. S., Garcia-Roman, R., Villa-Trevino, S., and Vasquez-Garzon, V. R. 2015 The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker. Tumor Biology 1-8.

  2. Flores-Tellez T., Lopez T., Vasquez-Garzon V.R. and Villa-Trevino S. 2015. Co-Expression of Ezrin-CLIC5-Podocalyxin is associated with migration and invasiveness in hepatocellular carcinoma. PLoS One 10: e0131605.

  3. Vasquez-Garzon, V. R., Beltran-Ramirez, O., Salcido-Neyoy, M. E., Cervante-Anaya, N., and Villa-Trevino, S. 2015 Analysis of gene expression profiles as a tool to uncover tumor markers of liver cancer progression in a rat model. Biomedical reports 3: 167-172

  4. Martinez-Soriano P., Macias-Perez J.R., Velazquez A., Camacho-Enriquez B., Pretelin-Castillo G., Ruiz-Sanchez M.B., Abrego-Reyes V., Villa-Trevino S., Angeles E. 2015 Solvent-free synthesis of carboxylic acids and amide analogs of CAPE (Caffeic Acid Phenethyl Ester) under infrared irradiation conditions. Green and Sustainable Chemistry 5: 81-91


  5. Valencia Antunez, C.A., Taja Chayeb, L., Rodriguez-Segura, M.A., Lopez Alvarez, G.S., Garcia-Cuellar, C. and Villa-Trevino, S. 2014. DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncology reports 32: 2093-2103

  6. Alvarez-Gonzalez I., Garcia-Melo F., Vasquez-Garzon V., Villa-Trevino S., Madrigal-Santillan O., Morales-Gonzalez J.A., Mendoza-Perez J.A., Madrigal-Bujaidar E. 2014 Evaluation of blueberry juice in mouse azoxymethane-induced aberrant crypts and oxidative damage. Evidence-Based Complementary and Alternative Medicine Article ID: 379890.

  7. Sanchez-Rodriguez R., Torres-Mena J.E,, De-la-Luz-Cruz M., Bernal-Ramos G.A., Villa-Trevino S., Chagoya-Hazas V., Landero-Lopez L., Garcia-Roman R., Rouimi P., Del-Pozo-Yauner L., Melendez-Zajgla J. and Perez-Carreon J.I. 2014. Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. The International Journal of Biochemistry and Cell Biology 53: 186-194

  8. Torres Mena J.E., Sanchez Rodriguez R., Quintanar Jurado V., Mojica Espinosa R., Del Pozo Yauner L., Melendez Zajgla J., Villa-Trevino, S. and Perez Carreon J.I. 2014. Laser capture microdissection after γ-glutamyl transferase histochemistry: an optimization for gene expression analysis. Analytical Biochemistry 447: 126-132


  9. Macias-Perez, J.R., Beltran-Ramirez, O., Vasquez-Garzon, V.R., Salcido-Neyoy, M.E., Martinez-Soriano, P.A., Ruiz-Sanchez, M.B., Angeles, E. and Villa-Trevino, S. 2013 The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model. Anticancer Drugs 24: 394-405

  10. Aparicio-Bautista, D., Perez-Carreon, J.I., Gutierrez-Najera, N., Reyes-Grajeda, J.P., Arellanes-Robledo, J., Vasquez-Garzon, V.R., Jimenez-Garcia, M.N., Villa-Trevino, S. 2013 Comparative proteomic analysis of thiol proteins in the liver after oxidative stress induced by diethylnitrosamine. Biochimica et Biophysica Acta 1834: 2528-2538


  11. Vasquez-Garzon VR, Macias-Perez, J.R., Jimenez Garcia M.N., Villegas, Vanessa., Fattel, Samia. y Villa-Trevino S. 2012 The Chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis. Toxicologic Pathology 41: 857-863

  12. Beltran-Ramirez, O., Macias-Perez, R., Sierra-Santoyo, A., Villa-Trevino, S., 2012. Cancer prevention mediated by caffeic acid phenethyl ester involves Cyp2b1/2 modulation in hepatocarcinogenesis. Toxicologic Pathology 40: 466-472

  13. Vasquez-Garzon, V. R., Rouimi, P., Jouanin, I., Waeg, G., Zarkovic N., Villa-Trevino S., and Gueraud F. 2012. Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins. Toxicology Mechanisms and Methods 22: 296-304. doi: 10.3109/15376516.2012.657258.


  14. Beltran-Ramirez, O., Sokol, S., Le-Berre, V., Francois, J. M., Villa-Trevino, S., 2010 An approach to the study of gene expression in hepatocarcinogenesis initiation. Translational Oncology 3: 142-148

  15. Jimenez-Garcia, M. N., Arellanes-Robledo, J., Aparicio-Bautirta, D. I., Rodriguez-Segura, M. A., Villa-Trevino, S., Godina-Nava, J. J., 2010 Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver. BMC Cancer 10: 1-12

  16. Marquez-Quinones, A., Cipak, A., Zarkovic, K., Fattel-Fazenda, S., Villa-Trevino, S., Waeg, G., Zarkovic, N., Gueraud, F., 2010 HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats. Free Radical Research 44: 119-127

  17. Jimenez-Garcia, M. N., Arellanes-Robledo, J., Aparicio-Bautista, D. I., Rodriguez-Segura, M.A., Villa-Trevino, S., Godina-Nava, J.J. 2010. Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver. BMC Cancer 10:159


  18. Perez-Correon, J. I., Dargent, C., Merhi, M., Fattel-Fazenda, S., Arce-Popoca, E., Villa-Trevino, S., Rouimi, P., 2009. Tumor promoting and co-carcinogenic effects in medium-term rat hepatocarcinogenesis are not modified by co-administration of 12 pesticides in mixture at acceptable daily intake. Food and Chemical Toxicology 47: 540-546

  19. Salcido-Neyoy, M. E., Sierra-Santoyo, A., Beltran-Ramirez, O., Macias-Perez, J. R., Villa-Trevino, S., 2009. Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer. World Journal of Gastroenterolgy 15: 2345-2350

  20. Pacheco-Yepez, J., Campos-Rodriguez, R., Rojas-Hernandez, S., Serrano-Luna, J. J., Rivera-Aguilar, V., Villa-Trevino, S., Martinez Palomo, A., Tsutsumi, V., Shibayama, M., 2009. Differential expression of surface glycoconjugates on Entamoeba histolytica and Entamoeba dispar. Parasitology International 58: 171-177

  21. Vasquez-garzon, V. R., Arellanes-robledo, J., Garcia-Roman, R., Aparicio-bautista, D. I., Villa-Trevino, S., 2009. Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense Mechanism. Free Radical Research 43: 128-137


  22. Beltran-Ramirez, O., Aleman-Lazarini, L., Salcido-Neyoy, M., Hernandez-Garcia, S., Fattel-Fazenda, S., Arce-Popoca, E., Arellanes-Robledo, J., Garcia-Roman, R., Vazquez-Vazquez, P., Sierra-Santoyo, A., Villa-Trevino, S., 2008. Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450. Toxicological Sciences 104: 100-106

  23. Garcia-Roman, R., Salazar-Gonzalez, D., Rosas, S., Arellanes-Robledo, J., Beltran-Ramirez, O., Fattel-Fazenda, S., Villa-Trevino, S., 2008. The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Radical Research 42: 331-343

  24. Rasales-Reyes, T., de la Garza, M., Arias-Castro, C., Rodriguez-Mendiola, M., Fattel-Fazenda, S., Arce-Popoca, E., Hernandez-Garcia, S., Villa-Trevino, S., 2008. Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats. Journal of Ethnopharmacology 115: 381-386


  25. Marquez-Quinones, A., Paris, A., Roussel, B., Perez-Correon, J., Le Berre, V., Francois, J. M., Villa-Trevino, S., Gueraud, F., 2007. Proteasome activity deregulation in LEC rat hepatitis: following the insights of transcriptomic analysis. OMICS 11: 367-84

  26. Marquez, A., Villa-Trevino, S., Gueraud, F., 2007. The LEC rat: a useful model for studying liver carcinogenesis related to oxidative stress and inflammation. Redox Report 12: 35-39

  27. Garcia,Roman, R., Perez-Carreon, J. I., Marquez-Quinones, A., Salcido-Neyoy, E., Villa-Trevino, S., 2007. Persistent activation of NF-kappaB related to IkappaBs degradation profiles during early chemical hepatocarcinogenesis. Journal of Carcinogenesis 6: 1-11

  28. Marquez-Rosado, L., Trejo-Solis, C., Cabrales-Romero, M., Arce-Popoca, E., Sierra-Santoyo, A., Aleman-Lazarini, L., Fatel-Fazenda, S., Carrasco-Legleu, C. E., Villa-Trevino, S., 2007. Co-Carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model. Molecular Carcinogenesis 46: 524-533


  29. Barajas-Farigarias, L. M., Perez-Correon, J. I., Arce-Popoca, E., Fattel-Fazenda, S., Aleman-Lazarini, L., Hernandez-Garcia, S., Salcido-Neyoy, M., Cruz-Jimenez F. G., Camacho, J., Villa-Trevino, S., 2006. A dual and opposite effect of Calendula officinalis flower extract: chemoprotector and promoterin a rat hepatocarcinogenesis model. Planta Medica 72: 217-221

  30. Arellanes-Robledo, J., Marquez-Rosado, L., Perez-Carreon, J. I., Fattel-Fazenda, S., Aguirre-Garcia, J., Villa-Trevino, S., 2006. Celecoxib induces regression of putative preneoplastic lesions in rat liver. Anticancer Research 26: 1271-1280

  31. Carrasco-Legleu, C. E., Sanchez-Perez, Y., Marquez-Rosado, L., Fattel-Fazenda, S., Arce-Popoca, E., Hernandez-Garcia, S., Villa-Trevino, S., 2006. A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model. World Journal of Gastroenterology 12: 6779-6785

  32. Perez-Carreon, J. I., Lopez-Garcia, C., Fattel-Fazenda, S., Arce-Popoca, E., Aleman-Lazarini, L., Hernandez-Garcia, S., Le berre, V., Sokol, S., Francois, J. M., Villa-Trevino, S., 2006. Gene expression profile related to the progression of preneoplastic nodules toward hepatocellular carcinoma in rats. Neoplasia 8: 373-383

  33. Cabrales-Romero, M., Marquez-Rosado, L., Fattel-Fazenda, S., Trejo-Solis, C., Arce-Popoca, E., Aleman-Lazarini, L., Villa-Trevino, S., 2006. S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism. World Journal of Gastroenterology 12: 1895-1904


  34. Ordaz-Pichardo, C., Shibayama, M., Villa-Trevino, S., Arriaga-Alba, M., Angeles, E., de la Garza, M., 2005. Antiamoebic and toxicity studies of a carbamic acid derivative and its therapeutic effect in a hamster model of hepatic amoebiasis. Antimicrobuial Agents and Chemotherapy 49: 1160-1168

  35. Sanchez-Perez, Y., Carrasco-Legleu, C., Garcia-Cuellar, C., Perez-Carreon, J., Hernandez-Garcia, S., Salcido-Neyoy, M., Aleman-Lazarini, L., Villa-Trevino, S., 2005 Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. Cancer Letters 217: 25-32

  36. Marquez-Rosado, L., Trejo-Solis, M. C., Garcia-Cuellar, C. M., Villa-Trevino, S., 2005. Celecoxib, a cyclooxygenase-2 inhibitor, prevents induction of liver preneoplastic lesions in rats. Journal of Hepatology 43: 653-60

  37. Ordaz-Pichardo, C., Shibayama, M., Villa-Trevino, S., Arriaga-Alba, M., Angeles, E., de la Garza, M., 2005. Antiamoebic and toxicity studies of a carbamic acid derivative and its therapeutic effect in a hamster model of hepatic amoebiasis. Antimicrobial Agents and Chemotherapy 49: 1160-1168

  38. Reyes-Lopez, M., Villa-Trevino, S., Arriaga-Alba, M., Aleman-Lazarini, L., Rodriguez-Mendiola, M., Arias-Castro, C., Fattel-Fazenda, S., de la Garza, M., 2005. The amoebicidal aqueous extract from Castela texana possesses antigenotoxic and antimutagenic properties. Toxicology in Vitro 19: 91-97


  39. Arguello-Ramirez, J., Perez-Cardenas, E., Delgado-Chavez, R., Solorza-Luna, G., Villa-Trevino, S., Arenas-Huertero, F., 2004. Matrix metalloproteinases-2, -3, and -9 secreted by explants of benign and malignant lesions of the uterine cervix. International Journal of Gynecological Cancer 14: 333-340

  40. Carrasco-Legleu, C. E., Marquez-Rosado, L., Fattel-Fazenda, S., Arce-Popoca, E., Perez-Carreon, J. I., Villa-Trevino, S., 2004. Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay. International Journal of Cancer 108: 488-492

  41. Carrasco-Legleu, C. E., Marquez-Rosado, L. M., Fattel-Fazenda, S., Arce-Popoca, E., Perez-Carreon, J., Villa-Trevino, S., 2004. Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay. Int. J. Cancer: 108: 488-492

  42. Gonzales de Mejia, E., Ramirez-Mares, M.V., Arce-Popoca, E., Wallig, M., Villa-Trevino, S., 2004. Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa. Food and Chemical Toxicology 42: 509-516


  43. Gonzales-Avila, M., Arriaga-Alba, M., de la Garza, M., Hernandez-Pretelin, M., Dominguez-Ortiz, M. A., Fattel-Fazenda, S., Villa-Trevino, S., 2003. Antigenotoxic, antimutagenic and ROS scavenging activities of a Rhoeo discolor ethanolic crude extract. Toxicology in Vitro 17: 77-83


  44. Perez-Carreon, J.I., Cruz-Jimenez, G., Licea-Vega, J. A., Arce-Popoca, E., Fattel-Fazenda, S., Villa-Trevino, S., 2002. Genotoxic and anti-genotoxic properties of Calendula officinalis extracts in rat liver cell cultures treated with diethylnitrosamine. Toxicology in Vitro 16: 253-258


  45. Ramirez-Mares, M. V., Fatell, S., Villa-Trevino, S., Gonzales de Mejia, E., 1999. Protection of extract from leaves of Ardisia compressa against benomyl-induced cytotoxicity and genotoxicity in cultured rat hepatocytes. Toxicology in Vitro 13: 889-896


  46. Garcia-Gasca, T., Fatell, S., Villa-Trevino, S., Gonzales de Mejia, E.,1998. Efect of carotenoids against genotoxicity of diethylnitrosamine on rat hepatocytes. Toxicology in Vitro 12: 691-698


  47. Mendoza-Figueroa, T., Lopez-Revilla, R., Villa-Trevino, S., 1979. Dose-dependent DNA Ruptures Induced by the Procarcinogen Dimethylnitrosamine on Primary Rat Liver Cultures. Cancer Research 39: 3254-3257


  48. Craddock, M., Villa-Trevino, S., Magee, P. N., 1968. Occurrence of 7-methylguanine in nucleic acids of rat liver. The Biochemical Journal 107: 179-184


  49. Villa-Trevino, S., 1967. A possible mechanism of inhibition of protein synthesis by dimethylnitrosamine. The Biochemical Journal 105: 625-631


  50. Villa-Trevino, Shull, K. H., Farber, E., 1966. The Inhibition of liver ribonucleic acid synthesis by ethionine. The Journal of Biological Chemistry 241: 4670-4674


  51. Villa-Trevino, S., Farber, E., Staehelin, T., Wettstein, F. O., Noll, H., 1964. Breakdown and reassembly of rat liver ergosomes after administration of ethionine or puromycin. The Journal of Biological chemistry 239: 3826-3833


  52. Villa-Trevino, S., Shull, K. H., Farber, E., 1963. The role of adenosine triphosphate deficiency in ethionine-induced inhibition of protein synthesis. Journal of Biological Chemistry 238:1757-1763

Comments about the content of these page:

Saul Villa Ph. D.

Bashan Fuondation