Inna Khozin-Goldberg

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Publications in scientific journals


  1. Shemesh, Z., Leu, S., Khozin-Goldberg, I., Didi-Cohen, S., Zarka, A., Boussiba, S. 2016. Inducible expression of Haematococcus oil globule protein in the diatom Phaeodactylum tricornutum: Association with lipid droplets and enhancement of TAG accumulation under nitrogen starvation. Algal Research. 18: 321-331. doi.10.1016/j.algal.2016.07.002.


  2. Shtaida, N., Khozin-Goldberg, I., Boussiba, S. 2015. The role of pyruvate hub enzymes in supplying carbon precursors for fatty acid synthesis in photosynthetic microalgae. Photosynthesis Research. doi.10.1007/s11120-015-0136-7.

  3. Kaye, Y., Grundman, O., Leu, S., Zarka, A., Zorin, B., Didi-Cohen, S., Khozin-Goldberg, I., Boussiba, S. 2015. Metabolic engineering toward enhanced LC-PUFA biosynthesis in Nannochloropsis oceanica: Overexpression of endogenous Δ12 desaturase driven by stress-inducible promoter leads to enhanced deposition of polyunsaturated fatty acids in TAG. Algal Research. 11: 387-398. doi.10.1016/j.algal.2015.05.003.

  4. Abu-Ghosh, S., Pal-Nath, D., Markovitch, D., Solovchenko, A.M., Didi-Cohen, S., Portugal, I., Khozin-Goldberg, I., Cohen, Z., and Boussiba, S. 2015. A novel source of dihomo-γ-linolenic acid: possibilities and limitations of DHLA production in the high-density cultures of the Δ5 desaturase-mutant microalga Lobosphaera incisa. European Journal of Lipid Science and Technology. 117: 760-766. doi.10.1002/ejlt.201400430.


  5. Davidi, L., Shimoni, E., Khozin-Goldberg, I., Zamir, A., and Pick, U. 2014. Origin of β-carotene-rich Plastoglobuli in Dunaliella bardawil. Plant physiology 164: 2139-2156.

  6. Ventura, Y., Myrzabayeva, M., Alikulov, Z., Omarov, R., Khozin-Goldberg, I., and Sagi, M. 2014. Effects of salinity on flowering, morphology, biomass accumulation and leaf metabolites in an edible halophyte. AoB plants 6: plu053.

  7. Solovchenko, A.M., Lukyanov, A., Solovchenko, O., Didi-Cohen, S., Boussiba, S., and Khozin-Goldberg, I. 2014 Interactive effects of salinity, high light, and nitrogen starvation on fatty acid and carotenoid profiles in Nannochloropsis oceanica CCALA 804. European Journal of Lipid Science and Technology 116: 635-644


  8. Xue, W., Batushansky, A., Toubiana, D., Botnick, I., Szymanski, J., Khozin-Goldberg, I., Nikoloski, Z., Lewinsohn, E. and Fait, A. 2013. The investment in scent: time-resolved metabolic processes in developing volatile-producing Nigella sativa L. Seeds. PloS one 8: e73061.

  9. Solovchenko, A.M., Solovchenko, O., Khozin-Goldberg, I., Didi-Cohen, S., Pal, D., Cohen, Z., Boussiba, S. 2013 Probing the effects of high-light stress on pigment and lipid metabolism in nitrogen-starving microalgae by measuring chlorophyll fluorescence transients: Studies with a Δ5 desaturase mutant of Parietochloris incisa (Chlorophyta, Trebouxiophyceae). Algal Research 2: 175-182

  10. Solovchenko, A. and Khozin-Goldberg, I. 2013 High-CO2 tolerance in microalgae: possible mechanisms and implications for biotechnology and bioremediation. Biotechnology Letters 35: 1745-1752

  11. Pal D, Khozin-Goldberg I, Didi-Cohen S, Solovchenko A, Batushansky A, Kaye Y, Sikron N, Samani T, Fait A, Boussiba S. 2013 Growth, lipid production and metabolic adjustments in the euryhaline eustigmatophyte Nannochloropsis oceanica CCALA 804 in response to osmotic downshift. Applied Microbiology and Biotehcnology 97: 8291-8306


  12. Nath, P. R., Khozin-Goldberg, I., Cohen, Z., Boussiba, S., and Zilberg, D. (2012). Dietary supplementation with the microalgae Parietochloris incisa increases survival and stress resistance in guppy (Poecilia reticulata) fry. Aquaculture Nutrition 18: 167-180

  13. Grundman O, Khozin-Goldberg, I, Raveh D, Cohen Z, Vyazmensky M, Boussiba S, Shapira M. 2012 Cloning, mutagenesis, and characterization of the microalga Parietochloris incisa acetohydroxyacid synthase, and its possible use as an endogenous selection marker. Biotechnology and bioengineering 109: 2340-2348


  14. Guih-neuf F, Leu S, Zarka A, Khozin-Goldberg I, Khalilov I, Boussiba S. 2011 Cloning and molecular characterization of a novel acyl-CoA:diacylglycerol acyltransferase 1-like gene (PtDGAT1) from the diatom Phaeodactylum tricornutum. The FEBS Journal 278: 3651-3666

  15. Khozin-Goldberg, I. and Boussiba, S. 2011 Concerns over the reporting of inconsistent data on fatty acid composition for microalgae of the genus Nannochloropsis (Eustigmatophyceae). Journal of Applied Phycology 23: 933-934

  16. Peled, E., Leu, S., Zarka, A., Weiss, M., Pick, U., Khozin-Goldberg, I. and Boussiba, S. 2011 Isolation of a novel oil globule protein from the green alga Haematococcus pluvialis (Chlorophyceae). Lipids 46: 851-861

  17. Pal, D., Khozin-Goldberg, I., Cohen, Z. and Boussiba, S. 2011 The effect of light, salinity, and nitrogen availability on lipid production by Nannochloropsis sp. Applied Microbiolgy and Biotechnology 90: 1429-1441

  18. Iskandarov, U., Khozin-Goldberg, I. and Cohen, Z. 2011 Selection of a DGLA-producing mutant of the microalga Parietochloris incisa: I. Identification of mutation site and expression of VLC-PUFA biosynthesis genes. Applied Microbiolgy and Biotechnology 90: 249-256

  19. Khozin-Goldberg, I., Iskandarov, U. and Cohen, Z. 2011 LC-PUFA from photosynthetic microalgae: occurrence, biosynthesis, and prospects in biotechnology. Applied Microbiolgy and Biotechnology 91: 905-915


  20. Khozin-Goldberg, I., Cohen, Z. 2010 Unraveling algal lipid metabolism: Recent advances in gene identification. Biochimie 93: 91-100

  21. Iskandarov, U., Khozin-Goldberg, I. and Cohen, Z. 2010 Identification and characterization of Δ12, Δ6, and Δ5 desaturases from the green microalga Parietochloris incisa. Lipids 45: 519-530


  22. McCue, M.D., Amitai, O., Khozin-Goldberg, I., McWilliams, S.R. and Pinshow, B. 2009 Effect of dietary fatty acid composition on fatty acid profiles of polar and neutral lipid tissue fractions in zebra finches, Taeniopygia guttata. Comparative Biochemistry and Physiology, Part A 154: 165-172

  23. Dagar, A., Zilberg, D., Cohen, Z., Boussiba, S. and Khozin-Goldberg, I. 2009 Short-term dietary supplementation with the microalga Parietochloris incisa enhances stress resistance in guppies Poecilia reticulata. Aquaculture Research doi:10.1111/j.1365-2109.2009.02329.x

  24. Iskandarov, U., Khozin-Goldberg, I., Ofir, R. and Cohen, Z. 2009 Cloning and characterization of the Δ6 polyunsaturated fatty acid elongase from the green microalga Parietochloris incisa. Lipids 44: 545-554.

  25. Solovchenko, A. E., Khozin-Goldberg, I., Cohen, Z. and Merzlyak, M. N. 2009 Carotenoid-to-chlorophyll ratio as a proxy for assay of total fatty acids and arachidonic acid content in the green microalga Parietochloris incisa. Journal of Applied Phycolgy 20: 361-366.


  26. Solovchenko, A. E., Khozin-Goldberg, I., Didi-Cohen, S., Cohen, Z. and Merzlyak, M. N. 2008 Effects of light intensity and nitrogen starvation on growth, total fatty acids and arachidonic acid in the green microalga Parietochloris incisa. Journal of Applied Phycolgy 20: 245-251

  27. Solovchenko, A. E., Khozin-Goldberg, I., Didi-Cohen, S., Cohen, Z. and Merzlyak, M. N. 2008 Effects of light and nitrogen starvation on the content and composition of carotenoids of the green microalga Parietochloris incisa. Russian Journal of Plant Physiology 55: 455-462.

  28. Solovchenko, A. E., Merzlyak, M. N., Chivkunova, O. B., Reshetnikova, I. V., Khozin-Goldberg, I. S. Didi-Cohen, S. and Cohen, Z. 2008 Effects of illumination and nitrogen starvation on accumulation of arachidonic acid by the microalga Parietochloris incisa. Moscow University Biological Sciences Bulletin 63: 44-48


  29. Pesakhov, S., Benisty, R., Sikron, N., Cohen, Z., Khozin-Goldberg, I., Dagan, R. and Porat, N. 2007 Effect of hydrogen peroxide production and the fenton reaction on membrane composition of Streptococcus pneumoniae. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768: 590-597

  30. Merzlyak, M. N., Chivkunova, O. B., Gorelova, O. A., Reshetnikova, I. V., Solovchenko, A. E., Khozin-Goldberg, I. and Cohen, Z. 2007 Effect of nitrogen starvation on optical properties, pigments and arachidonic acid content of the unicellular green alga Parietochloris incisa (trebouxiophyceae) chlorophyta. Journal of Phycology 43: 833-843


  31. Khozin-Goldberg, I. & Cohen, Z.2006 Effect of phosphate starvation on lipid and fatty acid composition of the eustigmatophyte Monodus subterraneus Phytochemistry 67: 696-701.

  32. Khozin-Goldberg, I., Cohen, Z., Pimenta-Leibowitz, M., Nechev, J. & Zilberg, D. 2006 Feeding with arachidonic acid-rich triacylglycerols from the microalga Parietochoris incisa increased recovery of guppies from infection with Tetrahymena sp. Aquaculture 255, 142-150.


  33. Zhekisheva, M., Zarka, A., Khozin-Goldberg, I., Cohen, Z. and Boussiba, S. 2005 Inhibition of astaxanthin synthesis under high irradiance does not abolish triacylglycerol accumulation in the green alga Haematococcus pluvialis (Chlorophyceae) Journal of Phycology 41: 819-826

  34. Khozin-Goldberg, I., Shrestha, P., and Cohen, Z. 2005 Mobilization of arachidonyl moieties from triacylglycerols into chloroplastic lipids following recovery from nitrogen starvation of the microalga Parietochloris incisa. Biochimica et Biophysica Acta 1738: 63-71.


  35. Aricha, B., Fishov, I., Cohen, Z., Sikron, N., Pesakhov, S., Khozin-Goldberg, I., Dagan, R., and Porat, N. 2004 Differences in membrane fluidity between phenotypic variants of Streptococcus pneumoniae. Journal of Bacteriology 186: 4638-4644.


  36. Ivanova, A., Khozin-Goldberg, I., Kamenarska, Z., Nechev, J., Cohen, Z., Popov, S., and Stefanov, K. 2003 Lipophylic compounds from Euphorbia peplis L. - a halophytic plant from the Bulgarian Black Sea coast. Zeitschrift fuer Naturforschung Section 58c: 783-788.


  37. Bigogno, C., Khozin-Goldberg, I., and Cohen, Z. 2002 Accumulation of arachidonic acid and triacylglycerols in the microalga Parietochloris incisa (Chlorophyceae). Phytochemistry 60 : 135-143.

  38. Bigogno, C., Khozin-Goldberg, I., Adlerstein, D., and Cohen, Z. 2002 Biosynthesis of arachidonic acid in the oleaginous microalga Parietochloris incisa (Chlorophyceae): Radiolabeling studies. Lipids 37: 209-216

  39. Khozin-Goldberg, I., Didi-Cohen, S., Shayakhmetova, I., and Cohen, Z. 2002 Biosynthesis of eicosapentaenoic acid (EPA) in the fresh water eustigmatophyte Monodus subterraneus. Journal of Phycology 38: 745-756.

  40. Cheng-Wu, Z., Cohen, Z., Khozin-Goldberg, I., and Richmond, A. 2002 Characterization of growth and arachidonic acid production of Parietochloris incisa comb. nov (Trebouxiophyceae, Chlorophyta). Journal of Applied Phycology 14: 453-460.

  41. Zhekisheva, M., Boussiba, S., Khozin-Goldberg, I., Zarka, A., and Cohen, Z. 2002 Accumulation of oleic acid in Haematococcus pluvialis (chlorophyceae) under nitrogen starvation or high light, is correlated with that of astaxanthin esters. Journal of Phycology 38: 325-31.

  42. Bigogno, C., Khozin-Goldberg, I., Boussiba, S., Vonshak, A., and Cohen, Z. 2002 Lipid and fatty acid composition of the green alga Parietochloris incisa. Phytochemistry 60: 497-503.

  43. Khozin-Goldberg, I., Bigogno, C. and Cohen, Z. 2002 Nitrogen starvation induced accumulation of arachidonic acid in the freshwater green alga Parietochloris incisa. Journal of Phycology 38: 991-994


  44. Cohen, Z., Khozin-Goldberg, I., Adlrestein, D., and Bigogno, C. 2000 The role of triacylglycerols as a reservoir of polyunsaturated fatty acids for the rapid production of chloroplastic lipids in certain microalgae. Biochemical Society Transactions 28: 740-743.

  45. Khozin-Goldberg, I., Yu, H. Z., Adlerstein, D., Didi-Cohen, S., Heimer, Y. M., and Cohen, Z. 2000 Triacylglycerols of the red microalga Porphyridium cruentum participate in the biosynthesis of eukaryotic galactolipids. Lipids 5: 881-889.

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Inna Khozin-Goldberg